I listen to lots of podcasts... here are some of my favorite ones of the geek persausion you can visit the sites and subscribe if you dare ... people will make fun of you..

Lullabot / Drupal Podcast I really like this one... total focus on Drupal and pretty funny at times.

php|architect's PRO::PHP podcastThis is pretty good -- news and interviews

WebDevRadio I have not listened to this one...

TWIT.TV is full of podcasts and runs on drupal